通过治疗药物监测成功确定慢性髓性白血病患者因急性肾功能不全开始透析时伊马替尼重新给药剂量的案例。
Successful determination of imatinib re-administration dosage by therapeutic drug monitoring in a case of chronic myeloid leukemia initiating dialysis for acute renal dysfunction.
作者信息
Nakahara Ryosuke, Sumimoto Takahiro, Tanaka Ryota, Ogata Masao, Itoh Hiroki
机构信息
Department of Clinical Pharmacy Oita University Hospital Oita Japan.
Department of Hematology Oita University Hospital Oita Japan.
出版信息
Clin Case Rep. 2021 Aug 16;9(8):e04357. doi: 10.1002/ccr3.4357. eCollection 2021 Aug.
Abstract
Fixed dose regimen is currently the standard administration method for TKI. However, this case report indicated that TDM may by a useful approach to individualized dosing of TKI for the treatment of CML when initiating dialysis.
摘要
固定剂量方案目前是酪氨酸激酶抑制剂（TKI）的标准给药方法。然而，该病例报告表明，在开始透析时，治疗药物监测（TDM）可能是一种用于TKI个体化给药治疗慢性粒细胞白血病（CML）的有用方法。
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