晚发型子痫前期女性血清组织蛋白酶B、D和L浓度的评估。
Evaluation of serum cathepsin B, D, and L concentrations in women with late-onset preeclampsia.
作者信息
Anık İlhan Gökçe, Yıldızhan Begüm
机构信息
Marmara University Faculty of Medicine, Department of Obstetrics and Gynecology, İstanbul, Turkey.
出版信息
Turk J Obstet Gynecol. 2019 Jun;16(2):91-94. doi: 10.4274/tjod.galenos.2019.40460. Epub 2019 Jul 3.
OBJECTIVE
The aim of the study was to assess serum cathepsin B, D, and L concentrations in women with late-onset preeclampsia.
MATERIALS AND METHODS
One hundred forty pregnant women were enrolled in the study, of which 100 subjects were preeclamptic and 40 were healthy controls. Serum concentrations of cathepsin B, D, and L were measured and compared between the preeclamptic and control groups.
RESULTS
Cathepsin B and D concentrations were significantly higher in the preeclamptic group compared with the control group. There was no statistically significant difference between the groups in terms of cathepsin L concentrations. Cathepsin B concentrations were significantly higher in women with preeclampsia with severe features compared with those with preeclampsia alone.
CONCLUSION
Women with late-onset preeclampsia have significantly higher serum cathepsin B and D concentrations than controls. Cathepsin B and D may be promising biomarkers in women with late-onset preeclampsia.
目的
本研究旨在评估晚发型子痫前期女性血清组织蛋白酶B、D和L的浓度。
材料与方法
140名孕妇纳入本研究，其中100名为子痫前期患者，40名为健康对照。测量并比较子痫前期组和对照组血清组织蛋白酶B、D和L的浓度。
结果
子痫前期组组织蛋白酶B和D的浓度显著高于对照组。两组间组织蛋白酶L浓度无统计学显著差异。重度子痫前期女性的组织蛋白酶B浓度显著高于单纯子痫前期女性。
结论
晚发型子痫前期女性血清组织蛋白酶B和D浓度显著高于对照组。组织蛋白酶B和D可能是晚发型子痫前期女性有前景的生物标志物。
Zotero 插件