使用利妥昔单抗治疗后，类风湿关节炎相关支气管扩张出现显著恶化。
Marked deterioration in rheumatoid arthritis associated bronchiectasis following treatment with Rituximab.
作者信息
Musameh K, Campbell C D, Rutherford R M
机构信息
Department of Respiratory Medicine, University Hospital Galway, Galway, Ireland.
出版信息
Respir Med Case Rep. 2019 Jul 11;28:100904. doi: 10.1016/j.rmcr.2019.100904. eCollection 2019.
We report a 67 year old lady with Rheumatoid Arthritis (RA) and mild bronchiectasis (BE) whose treatment was escalated to Rituximab. Nine months after commencing Rituximab her lung sepsis worsened dramatically with repeated hospitalization, new sputum isolation of and and marked radiological deterioration in BE. She was found to have a low serum IgG and IgM levels almost certainly as a complication of Rituximab. Immunoglobulin replacement therapy was instituted and her clinical status has slowly improved.
我们报告了一位67岁患有类风湿性关节炎（RA）和轻度支气管扩张（BE）的女性患者，其治疗方案升级为使用利妥昔单抗。在开始使用利妥昔单抗九个月后，她的肺部脓毒症急剧恶化，反复住院，新的痰液中分离出……，并且支气管扩张的影像学表现明显恶化。几乎可以肯定，她血清中的免疫球蛋白G（IgG）和免疫球蛋白M（IgM）水平较低是利妥昔单抗的并发症。于是开始进行免疫球蛋白替代疗法，她的临床状况已慢慢改善。 （原文中“新的痰液中分离出……”处内容不完整）
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