载脂蛋白A2在染色体上定位于1号染色体长臂2区1带至2区3带。
Regional chromosomal localisation of APOA2 to 1q21-1q23.
作者信息
Middleton-Price H R, van den Berghe J A, Scott J, Knott T J, Malcolm S
机构信息
Mothercare Department of Paediatric Genetics, Institute of Child Health, London, UK.
出版信息
Hum Genet. 1988 Jul;79(3):283-5. doi: 10.1007/BF00366253.
PMID:3136074
Abstract
Using in situ hybridisation, we have mapped APOA2 to the 1q21-1q23 region of chromosome 1. DNA hybridisation to somatic cell hybrids made from cells carrying a balanced translocation between X and 1 confirms the localisation as proximal to 1q23. This was further confirmed by the presence of two polymorphic alleles in a cell line carrying a deletion of 1q25-1q32.
摘要
我们通过原位杂交技术将载脂蛋白A2（APOA2）基因定位到了1号染色体的1q21 - 1q23区域。对由携带X染色体与1号染色体之间平衡易位的细胞构建的体细胞杂种进行DNA杂交，证实该基因定位在靠近1q23的位置。在一个携带1q25 - 1q32缺失的细胞系中存在两个多态性等位基因，进一步证实了这一定位。
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