Abedini Robabeh, Goodarzi Azadeh, Saeidi V, Hosseini Seyedeh H, Jadidnuri Atefeh, Salehi Taleghani Mehrnaz, Lajevardi Vahide
Tehran University of Medical Sciences, Razi Hospital, Department of Dermatology, Tehran, Iran.
Dermatology Department, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Int J Womens Dermatol. 2019 Mar 2;5(3):171-174. doi: 10.1016/j.ijwd.2018.12.004. eCollection 2019 Jul.
One of the most important organ involvements in psoriasis is atherosclerotic cardiovascular disease. Homocysteine is known to have atherogenic properties, but some inconsistency exists in the literature about its probable role as a risk factor of cardiovascular disorder in patients with psoriasis.
Because of some controversies, we compared homocysteine levels and related parameters of metabolic cycles in patients with psoriasis and healthy individuals.
This case-control study was conducted on 50 patients with psoriasis and 50 healthy individuals as the controls. Serum homocysteine, vitamin B12 levels, and erythrocyte folate concentrations were checked in all participants.
Mean serum homocysteine, erythrocyte folate, and vitamin B12 levels did not show any significant difference between the two groups ( > .05), but interestingly, in patients with psoriasis, men had a significantly higher incidence of hyperhomocysteinemia and lower levels of erythrocyte folate ( = .14). Overall, there is no significant difference in serum levels of homocysteine and metabolic-related parameters between the case and control group. There was no significant relationship between the severity of psoriasis and the body mass index of patients ( > .05).
Patients with psoriasis had a higher body mass index and higher levels of homocysteine in men. Hyperhomocysteinemia could be a predisposing factor of cardiovascular events, but more evaluations as a part of metabolic syndrome in patients with psoriasis are needed.
银屑病最重要的器官受累情况之一是动脉粥样硬化性心血管疾病。同型半胱氨酸已知具有致动脉粥样硬化特性，但关于其作为银屑病患者心血管疾病危险因素的潜在作用，文献中存在一些不一致之处。
由于存在一些争议，我们比较了银屑病患者和健康个体的同型半胱氨酸水平及代谢周期相关参数。
本病例对照研究对50例银屑病患者和50名健康个体作为对照进行。检测了所有参与者的血清同型半胱氨酸、维生素B12水平和红细胞叶酸浓度。
两组之间的平均血清同型半胱氨酸、红细胞叶酸和维生素B12水平均未显示出任何显著差异（P＞0.05），但有趣的是，在银屑病患者中，男性高同型半胱氨酸血症的发生率显著更高，且红细胞叶酸水平更低（P = 0.14）。总体而言，病例组和对照组之间血清同型半胱氨酸水平及代谢相关参数无显著差异。银屑病的严重程度与患者的体重指数之间无显著关系（P＞0.05）。
银屑病患者的体重指数较高，男性的同型半胱氨酸水平较高。高同型半胱氨酸血症可能是心血管事件的一个易感因素，但作为银屑病患者代谢综合征一部分，还需要更多评估。
