水中有机磷化合物的分子识别及其对乙酰胆碱酯酶毒性的抑制。
Molecular recognition of organophosphorus compounds in water and inhibition of their toxicity to acetylcholinesterase.
机构信息
Department of Chemistry, The University of Hong Kong, Hong Kong, China.
出版信息
Chem Commun (Camb). 2019 Aug 13;55(66):9797-9800. doi: 10.1039/c9cc04603h.
PMID:31360962
Abstract
Molecular tubes with hydrogen bonding donors in their deep hydrophobic cavities are able to selectively bind organophosphorus compounds in water through hydrogen bonding and the hydrophobic effect. They can also be used as a fluorescent sensor for nerve agent simulants and as an inhibitor to reduce the toxicity of paraoxon to acetylcholinesterase.
摘要
具有氢键供体的分子管在其深疏水性腔内能够通过氢键和疏水作用选择性地在水中结合有机磷化合物。它们还可以用作神经毒剂模拟物的荧光传感器，并作为抑制剂来降低对氧磷对乙酰胆碱酯酶的毒性。
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