Department of Ophthalmology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, PR China.
State Key Laboratory for Modification of Chemical Fibers & Polymer Materials, College of Chemistry, Chemical Engineering & Biotechnology, Donghua University, Shanghai, 201620, PR China.
Nanomedicine (Lond). 2019 Oct;14(19):2595-2611. doi: 10.2217/nnm-2019-0008. Epub 2019 Jul 30.
To improve the retention of fluorescein sodium (FS) as a kind of clinical contrast agent for fundus fluorescein angiography (FFA). Polyethyleneimine (PEI) was designed to synthesize PEI-NHAc-FS nanoparticles (NPs), and the formed NPs were characterized by both physicochemical properties and their effects on FFA. Compared with free FS, PEI-NHAc-FS NPs showed similar optical performance, and could obviously reduce cellular adsorption and uptake both and , which could promote the metabolism of NPs in ocular blood vessels. PEI-NHAc-FS NPs represent a smart nanosize fluorescence contrast agent, which hold promising potential for clinical FFA diagnosis, therapy and research work.
为了提高荧光素钠（FS）作为眼底荧光血管造影（FFA）临床造影剂的保留率。设计聚乙烯亚胺（PEI）合成 PEI-NHAc-FS 纳米颗粒（NPs），并通过理化性质及其对 FFA 的影响来表征所形成的 NPs。与游离 FS 相比，PEI-NHAc-FS NPs 表现出相似的光学性能，并且可以明显减少细胞吸附和摄取，这可以促进 NPs 在眼部血管中的代谢。PEI-NHAc-FS NPs 代表了一种智能纳米荧光对比剂，为临床 FFA 诊断、治疗和研究工作提供了有前途的应用。
