聚乙烯亚胺负载的荧光素钠用于眼底荧光血管造影可提高黏附性。
Fluorescein sodium loaded by polyethyleneimine for fundus fluorescein angiography improves adhesion.
机构信息
Department of Ophthalmology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, PR China.
State Key Laboratory for Modification of Chemical Fibers & Polymer Materials, College of Chemistry, Chemical Engineering & Biotechnology, Donghua University, Shanghai, 201620, PR China.
出版信息
Nanomedicine (Lond). 2019 Oct;14(19):2595-2611. doi: 10.2217/nnm-2019-0008. Epub 2019 Jul 30.
To improve the retention of fluorescein sodium (FS) as a kind of clinical contrast agent for fundus fluorescein angiography (FFA). Polyethyleneimine (PEI) was designed to synthesize PEI-NHAc-FS nanoparticles (NPs), and the formed NPs were characterized by both physicochemical properties and their effects on FFA. Compared with free FS, PEI-NHAc-FS NPs showed similar optical performance, and could obviously reduce cellular adsorption and uptake both and , which could promote the metabolism of NPs in ocular blood vessels. PEI-NHAc-FS NPs represent a smart nanosize fluorescence contrast agent, which hold promising potential for clinical FFA diagnosis, therapy and research work.
为了提高荧光素钠（FS）作为眼底荧光血管造影（FFA）临床造影剂的保留率。设计聚乙烯亚胺（PEI）合成 PEI-NHAc-FS 纳米颗粒（NPs），并通过理化性质及其对 FFA 的影响来表征所形成的 NPs。与游离 FS 相比，PEI-NHAc-FS NPs 表现出相似的光学性能，并且可以明显减少细胞吸附和摄取，这可以促进 NPs 在眼部血管中的代谢。PEI-NHAc-FS NPs 代表了一种智能纳米荧光对比剂，为临床 FFA 诊断、治疗和研究工作提供了有前途的应用。
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