全血二氧化碳含量的计算。

Calculation of whole blood CO2 content.

作者信息

Douglas A R, Jones N L, Reed J W

机构信息

Department of Physiological Sciences, The Medical School, University of Newcastle upon Tyne, United Kingdom.

出版信息

J Appl Physiol (1985). 1988 Jul;65(1):473-7. doi: 10.1152/jappl.1988.65.1.473.

DOI:10.1152/jappl.1988.65.1.473

PMID:3136136

Abstract

Currently used methods for calculating whole blood CO2 content from calculated plasma content, measured blood pH, hemoglobin concentration ([Hb]), and O2 saturation yield materially different results. In this study the constants of the fundamental equations relating blood CO2 content to plasma content have been reevaluated. An iterative computer technique was used to empirically derive appropriate constants from data obtained from nine healthy male subjects at rest and at several exercise work loads. A calculation was derived that fitted the data well [difference 0.02 +/- 1.19 ml/100 (SD) ml, r = 0.98] blood CCO2 = plasma CCO2 (Formula: see text) where plasma CCO2 = 2.226.s.plasma PCO2.(1 + 10pH-pK'), CCO2 is CO2 content, SO2 is O2 saturation, s is the plasma CO2 solubility coefficient, and pK' is the apparent pK [s and pK' are from the equations of Kelman (Respir. Physiol. 3: 111-115, 1967)].

摘要

目前，根据计算得出的血浆含量、测量的血液pH值、血红蛋白浓度（[Hb]）和氧饱和度来计算全血二氧化碳含量的方法会产生显著不同的结果。在本研究中，对血液二氧化碳含量与血浆含量之间基本方程的常数进行了重新评估。采用迭代计算机技术，根据九名健康男性受试者在静息状态和几种运动负荷下获得的数据，凭经验推导出合适的常数。得出了一个与数据拟合良好的计算式[差值为0.02±1.19毫升/100（标准差）毫升，r = 0.98]：血液CCO2 = 血浆CCO2（公式：见正文），其中血浆CCO2 = 2.226×血浆PCO2×(1 + 10pH - pK')，CCO2为二氧化碳含量，SO2为氧饱和度，s为血浆二氧化碳溶解度系数，pK'为表观pK[s和pK'来自凯尔曼的方程（《呼吸生理学》3：111 - 115，1967年）]。