电催化三组分反应：氰基官能化咪唑稠合杂环的合成
Electrocatalytic Three-Component Reaction: Synthesis of Cyanide-Functionalization Imidazo-Fused -Heterocycles.
作者信息
Qian Peng, Zhou Zhenghong, Hu Kangfei, Wang Jiawei, Li Zhibin, Zha Zhenggen, Wang Zhiyong
机构信息
Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Soft Matter Chemistry & Center for Excellence in Molecular Synthesis of Chinese Academy of Sciences, Collaborative Innovation Center of Suzhou Nano Science and Technology & School of Chemistry and Materials Science , University of Science and Technology of China , Hefei , Anhui 230026 , People's Republic of China.
College of Chemistry and Material Engineering , Fuyang Normal University , Fuyang , Anhui 236037 , People's Republic of China.
出版信息
Org Lett. 2019 Aug 16;21(16):6403-6407. doi: 10.1021/acs.orglett.9b02317. Epub 2019 Jul 30.
An electrochemical three-component cyclization was developed under metal-free conditions, which provides a novel and facile approach for the construction of cyanide-functionalization imidazo-fused -heterocycles. A variety of cyanide-functionalization imidazo-fused -heterocycles can be obtained from easily available methyl -heteroaromatics, primary alkylamines, and trimethylsilyl cyanide with good to excellent yields. The reaction features a broad scope of substrates, scalability, and mild conditions.
在无金属条件下开发了一种电化学三组分环化反应，该反应为构建氰基官能化咪唑稠合杂环提供了一种新颖且简便的方法。从易于获得的甲基杂芳烃、伯烷基胺和三甲基硅基氰化物中可以以良好至优异的产率获得多种氰基官能化咪唑稠合杂环。该反应具有底物范围广、可扩展性强和条件温和的特点。
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