Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Soft Matter Chemistry & Center for Excellence in Molecular Synthesis of Chinese Academy of Sciences, Collaborative Innovation Center of Suzhou Nano Science and Technology & School of Chemistry and Materials Science , University of Science and Technology of China , Hefei , Anhui 230026 , P. R. China.
Org Lett. 2018 Oct 19;20(20):6359-6363. doi: 10.1021/acs.orglett.8b02578. Epub 2018 Oct 3.
An efficient NHI-mediated intermolecular annulation of methyl N-heteroaromatics with amines/amino acids was developed by virtue of anodic oxidation, providing a variety of functionalized imidazo-fused N-heterocycles with good to excellent yields. The practicality of this protocol was demonstrated by the readily available starting materials, broad substrate scope, water tolerance, scalability, and the diverse transformations of the electrolysis product.
通过阳极氧化，发展了一种高效的 NHI 介导的 N-杂芳基甲基化合物与胺/氨基酸的分子内环化反应，以良好至优秀的收率得到了多种功能化的咪唑并稠合的 N-杂环化合物。该协议的实用性通过易得的起始原料、广泛的底物范围、耐水性、可扩展性以及电解析产物的多样化转化得到了证明。
