Terzieva Velislava, Mihova Antoaneta, Altankova Iskra, Velikova Tsvetelina, Donchev Deyan, Uzunova Jordanka, Goncharov Andrey, Jurukova Nonka, Georgieva Viktoriya, Yordanova Emilia, Sekulovski Metodija, Chalamanov Ognian, Spassov Lubomir
1Clinical Immunology Laboratory, University Hospital "Lozenetz," Sofia University "St. Kliment Ohridski," Sofia, Bulgaria.
2Laboratory of Microbiology and Virology, University Hospital "Lozenetz," Sofia University "St. Kliment Ohridski," Sofia, Bulgaria.
Monoclon Antib Immunodiagn Immunother. 2019 Aug;38(4):137-144. doi: 10.1089/mab.2019.0010. Epub 2019 Jul 30.
Among multiple parameters, applied in the immunologic monitoring of transplantation, the levels of serum soluble CD30 (sCD30) and peripheral regulatory T cells (Tregs) are very promising. These are relatively new biomarkers, considered to reflect immune activation and tolerance in solid organ transplantation. Results are shown here from a preliminary study on the relevance of sCD30 and Tregs in the monitoring of the early post-transplantation period. Sixteen patients with chronic liver or kidney disease were examined. Nine of them were further selected for transplantation. Follow-up of sCD30 and Tregs was carried out during the first month after transplantation. Until day 30 (D30) after transplantation, a progressive decrease in sCD30 levels was observed in all patients. Conversely, the dynamic of Tregs was dependent on the transplanted organ: in liver recipients, an increase of Tregs was detected at day 7 (D7) followed by a gradual decrease until D30, whereas in kidney recipients, a sustained downward trend starting on D7 was observed. In liver recipients, the increase in Tregs preceded albumin normalization, whereas in kidney recipients, sCD30 was found to have predictive significance for the creatinine levels. Our results demonstrated that peripheral blood sCD30 and Tregs are valuable parameters in the immunologic monitoring of transplanted patients.
在用于移植免疫监测的多个参数中，血清可溶性CD30（sCD30）水平和外周调节性T细胞（Tregs）很有前景。这些是相对较新的生物标志物，被认为可反映实体器官移植中的免疫激活和耐受情况。本文展示了一项关于sCD30和Tregs在移植后早期监测中的相关性的初步研究结果。对16例慢性肝病或肾病患者进行了检查。其中9例进一步接受了移植手术。在移植后的第一个月内对sCD30和Tregs进行了随访。在移植后直至第30天（D30），所有患者的sCD30水平均呈逐渐下降趋势。相反，Tregs的动态变化取决于移植器官：在肝移植受者中，在第7天（D7）检测到Tregs增加，随后逐渐下降直至D30，而在肾移植受者中，从D7开始观察到持续下降趋势。在肝移植受者中，Tregs增加先于白蛋白恢复正常，而在肾移植受者中，发现sCD30对肌酐水平具有预测意义。我们的结果表明，外周血sCD30和Tregs是移植患者免疫监测中有价值的参数。
