Post-Graduation Program in Genetics and Molecular Biology, PPGBM, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Laboratory of Medical Genetics and Evolution, Genetics Department, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Laboratory of Genomic Medicine, Center of Experimental Research, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; National Institute of Medical Population Genetics, INAGEMP, Porto Alegre, Brazil; Sistema Nacional de Informação sobre Agentes Teratogênicos, SIAT, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Laboratory of Medical Genetics and Evolution, Genetics Department, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Laboratory of Genomic Medicine, Center of Experimental Research, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Reprod Toxicol. 2019 Sep;88:67-75. doi: 10.1016/j.reprotox.2019.07.015. Epub 2019 Jul 27.
The recognition of molecular mechanisms of a teratogen can provide insights to understand its embryopathy, and later to plan strategies for the prevention of new exposures. In this context, experimental research is the most invested approach. Despite its relevance, these assays require financial and time investment. Hence, the evaluation of such mechanisms through systems biology rise as an alternative for this conventional methodology. Systems biology is an integrative field that connects experimental and computational analyses, assembling interaction networks between genes, proteins, and even teratogens. It is a valid strategy to generate new hypotheses, that can later be confirmed in experimental assays. Here, we present a literature review of the application of systems biology in embryo development and teratogenesis studies. We provide a glance at the data available in public databases, and evaluate common mechanisms between different teratogens. Finally, we discuss the advantages of using this strategy in future teratogenesis researches.
致畸物分子机制的识别可以帮助我们深入了解其胚胎病，并为预防新的暴露提供策略。在这方面，实验研究是最受关注的方法。尽管如此，这些检测方法需要资金和时间投入。因此，通过系统生物学来评估这些机制成为了对传统方法的替代。系统生物学是一个整合的领域，它将实验和计算分析联系起来，构建基因、蛋白质甚至致畸物之间的相互作用网络。这是一种生成新假说的有效策略，这些假说可以在后续的实验中得到验证。在这里，我们回顾了系统生物学在胚胎发育和致畸研究中的应用。我们介绍了公共数据库中可用的数据，并评估了不同致畸物之间的常见机制。最后，我们讨论了在未来的致畸研究中使用这种策略的优势。
