Anderson R E, Whitney J B, Schiewe M C
Southern California Center for Reproductive Medicine, Newport Beach, CA, United States; Ovation Fertility, ART Lab, Newport Beach, CA, United States.
Ovation Fertility, ART Lab, Newport Beach, CA, United States.
Eur J Med Genet. 2020 Feb;63(2):103731. doi: 10.1016/j.ejmg.2019.103731. Epub 2019 Jul 27.
The clinical application of a PGT-A program implementing single euploid embryo transfer is evaluated over a 6.5 year period, beginning with its early validation phases. Euploidy embryo status is inversely correlated to oocyte source age and positively correlated to blastocyst quality grades. However, once a single euploid embryo is transferred, high levels of implantation and live birth success are attained independent of patient age and embryo quality, with only AA blastocysts exhibiting improved implantation. Factors influencing successful outcomes are discussed, including the management of mosaic NGS profiles. Overall, distinct advantages to a dedicated PGT-A/single euploid embryo transfer program are clearly evident in per cycle start comparisons to control cycles and national average statistics by age groups.
从早期验证阶段开始，对实施单倍体整倍体胚胎移植的植入前基因检测-非整倍体（PGT-A）程序进行了6.5年的临床应用评估。整倍体胚胎状态与卵母细胞来源年龄呈负相关，与囊胚质量等级呈正相关。然而，一旦移植单个整倍体胚胎，无论患者年龄和胚胎质量如何，都能获得高水平的着床和活产成功率，只有AA级囊胚着床率有所提高。讨论了影响成功结果的因素，包括嵌合NGS图谱的处理。总体而言，在与对照周期和按年龄组划分的全国平均统计数据的每个周期开始比较中，专用PGT-A/单整倍体胚胎移植程序的明显优势显而易见。
