从西班牙鼠尾草的地上部分提取的新穿心莲烷二萜类化合物及其心脏保护作用。
Neo-clerodane diterpenoids from aerial parts of Salvia hispanica L. and their cardioprotective effects.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, PR China; College of Pharmaceutical Science, Dali University, Dali, 671000, PR China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, PR China.
出版信息
Phytochemistry. 2019 Oct;166:112065. doi: 10.1016/j.phytochem.2019.112065. Epub 2019 Jul 27.
Ten undescribed neo-clerodane diterpenoids, named hispanins A-J, together with six known ones, were isolated from the aerial parts of Salvia hispanica L. Their structures were established by extensive spectroscopic analysis. The absolute configurations of the undescribed compounds were determined by the ECD data and single crystal X-ray diffraction analysis. Hispanins B and C represented the first neo-clerodane diterpenoids with a unique oxygen bridge between C-19 and C-20. All isolated compounds were evaluated for their protective effects against HO-induced cardiomyocyte injury. Five of these compounds showed significant cardioprotective effects.
从西班牙鼠尾草（Salvia hispanica L.）的地上部分分离得到了 10 个未被描述的新 clerodane 二萜类化合物，命名为 hispanin A-J，以及 6 个已知化合物。通过广泛的光谱分析确定了它们的结构。通过 ECD 数据和单晶 X 射线衍射分析确定了未描述化合物的绝对构型。化合物 B 和 C 代表了具有独特的 C-19 和 C-20 之间氧桥的第一个新 clerodane 二萜类化合物。所有分离得到的化合物均评估了其对 HO 诱导的心肌细胞损伤的保护作用。其中 5 种化合物表现出显著的心脏保护作用。
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