西班牙鼠尾草地上部分中的重排新穿心莲烷二萜类化合物
Rearranged neoclerodane diterpenoids from the aerial parts of Salvia hispanica L.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China; College of Pharmacy and Chemistry, Dali University, Dali 671000, PR China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
出版信息
Fitoterapia. 2020 Oct;146:104672. doi: 10.1016/j.fitote.2020.104672. Epub 2020 Jun 15.
Six new rearranged neoclerodane diterpenoids (1-6), as well as three known ones, were obtained from the aerial part of Salvia hispanica L. Their structures were elucidated by extensive analysis of spectroscopic data (1D, 2D NMR, and HRESIMS) and Mosher's method. The absolute configurations of 1, 2, and 4 were determined by single-crystal X-ray diffraction analysis. All isolated compounds were evaluated for their cardioprotective effects against HO-induced cardiomyocytes injury, and compound 5 showed statistically significant cardioprotective effect in vitro assays.
从西班牙鼠尾草（Salvia hispanica L.）的地上部分中分离得到了 6 个新的重排新穿心莲烷二萜（1-6），以及 3 个已知化合物。通过对光谱数据（1D、2D NMR 和 HRESIMS）和 Mosher 法的广泛分析，阐明了它们的结构。通过单晶 X 射线衍射分析确定了 1、2 和 4 的绝对构型。所有分离得到的化合物都进行了 HO 诱导的心肌细胞损伤的心脏保护作用评估，化合物 5 在体外试验中表现出统计学上显著的心脏保护作用。
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