具有免疫抑制活性的维吾尔药荒漠鼠尾草中的 clerodane 二萜。
Clerodane diterpenoids from the Uygur medicine Salvia deserta with immunosuppressive activity.
机构信息
State Key Laboratory of Southwestern Chinese Medicine Resources, and Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China.
College of Bioscience and Biotechnology, Shenyang Agricultural University, Shenyang 110866, PR China.
出版信息
Phytochemistry. 2023 Oct;214:113823. doi: 10.1016/j.phytochem.2023.113823. Epub 2023 Aug 12.
Six undescribed clerodane diterpenoids along with five known ones were isolated from the aerial parts of Salvia deserta, a traditional Uygur medicine. Their chemical structures including absolute configurations were elucidated by extensive spectroscopic analysis (including 1D and 2D NMR, HRESIMS, and IR), combined with calculated ECD method and single-crystal X-ray diffraction analysis. All the compounds possessed a terminal α,β-unsaturated-γ-lactone moiety, and were assayed for their immunosuppressive activity via inhibiting the secretion of cytokines TNF-α and IL-6 in macrophages RAW264.7. Among them, (5R,8R,9S,10R)-18-nor-cleroda-2,13-dien-16,15-olide-4-one obviously suppressed the secretion of TNF-α and IL-6 with IC values of 8.55 and 13.65 μM, respectively.
从传统维吾尔药物荒漠鼠尾草的地上部分分离得到了 6 个未描述的 clerodane 二萜类化合物和 5 个已知化合物。通过广泛的光谱分析（包括 1D 和 2D NMR、HRESIMS 和 IR），结合计算的 ECD 方法和单晶 X 射线衍射分析，阐明了它们的化学结构包括绝对构型。所有化合物都具有末端的α,β-不饱和-γ-内酯部分，并通过抑制巨噬细胞 RAW264.7 中细胞因子 TNF-α 和 IL-6 的分泌来测定它们的免疫抑制活性。其中，(5R,8R,9S,10R)-18-nor-cleroda-2,13-dien-16,15-olide-4-one 明显抑制 TNF-α 和 IL-6 的分泌，IC 值分别为 8.55 和 13.65 μM。
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