Department of Science and Technology, University of Sannio, Via De Sanctis snc, 82100 Benevento, Italy.
Department of Science and Technology, University of Sannio, Via De Sanctis snc, 82100 Benevento, Italy.
Colloids Surf B Biointerfaces. 2019 Oct 1;182:110380. doi: 10.1016/j.colsurfb.2019.110380. Epub 2019 Jul 18.
The present research deals with the evaluation of a clinoptilolite-rich rock, occurring in the Nižný Hrabovec deposit (Slovakia), for high-value technological applications based on sorption and in vitro release of nonsteroidal anti-inflammatory drugs (i.e., ibuprofen sodium salt). This georesource was surface modified (SMNZ) using four cationic surfactants. Results demonstrate that ibuprofen sorption is very fast and SMZNs can sorb up to ˜26 mg/g of drug as a function of the type of counterion and morphology of surfactant, as well as the hydrophobicity and molecular structure of the drug. Maximum sorption capacities observed for all SMNZs are fully comparable to other adsorbent carriers usually used for removal of contaminants in wastewaters. Sorption of ibuprofen is controlled by a dual mechanism: external anionic exchange and partition into the hydrophobic portion of the patchy bilayer. A prompt drug release in simulated intestinal fluid (SIF) was also observed, making this natural material also suitable to provide rapid soothing effects in potential pharmacological applications. Comparing the results of this study with other recent investigations, a good technological performance of clinoptilolite-rich rock can be inferred despite the relatively low zeolite content (˜56 wt.%).
本研究评价了一种富含斜发沸石的岩石，该岩石产自 Nižný Hrabovec 矿床（斯洛伐克），拟基于吸附作用和非甾体抗炎药物（如布洛芬钠盐）的体外释放，将其应用于高附加值的技术领域。该地质资源使用四种阳离子表面活性剂进行了表面改性（SMNZ）。结果表明，布洛芬的吸附非常迅速，SMZNs 可以吸附高达 ˜26mg/g 的药物，这取决于反离子的类型和表面活性剂的形态，以及药物的疏水性和分子结构。所有 SMNZs 的最大吸附容量都与通常用于去除废水中污染物的其他吸附载体完全相当。布洛芬的吸附受双重机制控制：外部阴离子交换和进入层状双层的疏水区。在模拟肠液（SIF）中也观察到了药物的快速释放，这使得这种天然材料也适合在潜在的药理学应用中提供快速舒缓效果。将本研究的结果与其他最近的研究进行比较，可以推断出尽管沸石含量相对较低（˜56wt.%），富含斜发沸石的岩石仍具有良好的技术性能。
