与教育相关的基因可预测美国老年人的脆弱程度。
Genes Related to Education Predict Frailty Among Older Adults in the United States.
机构信息
Institute of Behavioral Science, University of Colorado Boulder.
Institute for Behavioral Genetics, University of Colorado Boulder.
出版信息
J Gerontol B Psychol Sci Soc Sci. 2021 Jan 1;76(1):173-183. doi: 10.1093/geronb/gbz092.
OBJECTIVE
This article expands on research that links education and frailty among older adults by considering the role of genes associated with education.
METHOD
Data come from a sample of 7,064 non-Hispanic, white adults participating in the 2004-2012 waves of the Health and Retirement Study. Frailty was measured with two indices: (a) The Frailty Index which corresponds to a deficit accumulation model; and (b) The Paulson-Lichtenberg Frailty Index which corresponds to the biological syndrome/phenotype model. Genes associated with education were quantified using an additive polygenic score. Associations between the polygenic score and frailty indices were tested using a series of multilevel models, controlling for multiple observations for participants across waves.
RESULTS
Results showed a strong and negative association between genes for education and frailty symptoms in later life. This association exists above and beyond years of completed education and we demonstrate that this association becomes weaker as older adults approach their 80s.
DISCUSSION
The results contribute to the education-health literature by highlighting new and important pathways through which education might be linked to successful aging.
目的
本文通过研究与教育相关的基因在老年人虚弱中的作用，对老年人教育与虚弱之间的关系进行了扩展。
方法
数据来自于参加 2004 年至 2012 年“健康与退休研究”的 7064 名非西班牙裔白人成年人的样本。使用两种指数来衡量虚弱：（a）与缺陷积累模型对应的虚弱指数；（b）与生物学综合征/表型模型对应的保罗森-利希滕贝格虚弱指数。使用加性多基因评分来量化与教育相关的基因。使用一系列多层次模型来测试多基因评分与虚弱指数之间的关联，这些模型控制了参与者在不同波次中的多次观察。
结果
结果表明，教育相关基因与晚年的虚弱症状之间存在强烈的负相关关系。这种关联存在于完成的教育年限之上，并且我们证明，随着老年人接近 80 岁，这种关联会变得更弱。
讨论
这些结果通过强调教育与成功老龄化之间可能存在的新的重要途径，为教育健康文献做出了贡献。
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