Yamamoto Shota, Yamada Takafumi, Kubo Genki, Sakurai Kazuo, Yamaguchi Kazuo, Nakanishi Jun
International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.
Department of Chemistry, Kanagawa University, 2946 Tsuchiya, Hiratsuka, Kanagawa 259-1293, Japan.
Polymers (Basel). 2019 Jul 29;11(8):1254. doi: 10.3390/polym11081254.
In this study, the structure-function relationships of a series of polymersomes composed of well-defined amphiphilic diblock copolymers were investigated. The building blocks were synthesized by clicking hydrophobic polymers, synthesized beforehand, and commercially available poly(ethylene glycol) with photocleavable 2-nitrobenzyl compounds bearing alkyne and maleimide functionalities. All of the tested polymersomes preserved their hollow structures even after sufficient photoirradiation. Nevertheless, the release rate of an entrapped anionic fluorophore was highly dependent on the molecular weight and the type of hydrophobic polymer, as well as on the presence or absence of the charged end groups. Moreover, the polymersomes with a 2-nitrosobenzyl photolysis residue within the hydrophobic shells exhibited photo-induced payload release after complete photolysis. It was concluded that the payload release was mediated by photo-induced permeability changes of the hydrophobic shells rather than the decomposition of their overall structures.
在本研究中，对一系列由结构明确的两亲性二嵌段共聚物组成的聚合物囊泡的结构-功能关系进行了研究。构建模块是通过将预先合成的疏水性聚合物与带有炔烃和马来酰亚胺官能团的可光裂解2-硝基苄基化合物的市售聚乙二醇进行点击反应合成的。即使经过充分的光照射，所有测试的聚合物囊泡仍保持其空心结构。然而，包封的阴离子荧光团的释放速率高度依赖于疏水性聚合物的分子量和类型，以及带电端基的存在与否。此外，在疏水壳层内具有2-亚硝基苄基光解残余物的聚合物囊泡在完全光解后表现出光诱导的有效载荷释放。得出的结论是，有效载荷的释放是由疏水壳层的光诱导渗透性变化介导的，而不是其整体结构的分解。
