Department of Fluoro-Agrochemicals, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500007 India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India
Curr Med Chem. 2020;27(40):6864-6887. doi: 10.2174/0929867326666190729152440.
Imidazo[2,1-b]thiazole, a well-known fused five-membered hetrocycle is one of the most promising and versatile moieties in the area of medicinal chemistry. Derivatives of imidazo[2,1-b]thiazole have been investigated for the development of new derivatives that exhibit diverse pharmacological activities. This fused heterocycle is also a part of a number of therapeutic agents.
To review the extensive pharmacological activities of imidazo[2,1-b]thiazole derivatives and the new molecules developed between 2000-2018 and their usefulness.
Thorough literature review of all relevant papers and patents was conducted.
The present review, covering a number of aspects, is expected to provide useful insights in the design of imidazo[2,1-b]thiazole-based compounds and would inspire the medicinal chemists for a comprehensive and target-oriented information to achieve a major breakthrough in the development of clinically viable candidates.
咪唑并[2,1-b]噻唑是一种众所周知的稠合五元杂环，是药物化学领域中最有前途和多功能的部分之一。咪唑并[2,1-b]噻唑的衍生物已被用于开发具有多种药理活性的新衍生物。这个稠合杂环也是许多治疗剂的一部分。
综述咪唑并[2,1-b]噻唑衍生物的广泛的药理学活性以及 2000-2018 年间开发的新分子及其用途。
对所有相关论文和专利进行了全面的文献回顾。
本综述涵盖了多个方面，预计将为基于咪唑并[2,1-b]噻唑化合物的设计提供有用的见解，并为药物化学家提供全面和有针对性的信息，以在开发临床可行的候选药物方面取得重大突破。
