Department of Genetic and Eugenics,Changsha Hospital for Maternal and Child Health Care, Changsha, Hunan, 410011, China.
Department of Neurology, Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Curr Mol Med. 2019;19(9):699-703. doi: 10.2174/1566524019666190729113321.
This study aimed to explore the clinical effect of levetiracetam in the treatment of children with epilepsy.
136 children with epilepsy were selected from January 2017 to December 2017. According to the random number table method, they were divided into the experimental group and the conventional group, with 68 cases in each group. The conventional group was treated with valproate, while the experimental group was treated with levetiracetam. The effective rate, the cognitive function and the frequency of clonic seizures in the two groups were compared.
There was no significant difference in the total effective rate between the two groups (P>0.05). There was no significant difference in attention, executive ability, abstract and orientation scores between the two groups before treatment (P>0.05). After treatment, the focus of attention (106.54±6.56), executive ability (105.76±6.77), abstract and directional score (106.65±6.57) were significantly higher than that of the conventional group. The difference in the two groups was statistically significant (P<0.05). After 3 months of treatment, the frequency of myoclonic seizures (9.22±0.95) and the frequency of tonic-clonic seizures (11.68±1.36) were found to be significantly lower than those of the conventional group, and the difference between the two groups was statistically significant (P<0.05).
Levetiracetam is effective in the treatment of children with epilepsy. It can effectively improve the cognitive function of the patients, reduce the frequency of myoclonic seizures and tonic-clonic seizures, and has a high promotion value.
本研究旨在探讨左乙拉西坦治疗儿童癫痫的临床效果。
选取 2017 年 1 月至 2017 年 12 月收治的 136 例癫痫患儿，根据随机数字表法分为实验组和常规组，每组 68 例。常规组给予丙戊酸钠治疗，实验组给予左乙拉西坦治疗。比较两组的有效率、认知功能和阵挛性发作频率。
两组总有效率比较差异无统计学意义（P>0.05）。两组治疗前注意力、执行能力、抽象和定向评分比较差异无统计学意义（P>0.05）。治疗后，实验组注意力评分（106.54±6.56）、执行能力评分（105.76±6.77）、抽象和定向评分（106.65±6.57）均明显高于常规组，差异有统计学意义（P<0.05）。治疗 3 个月后，实验组肌阵挛性发作频率（9.22±0.95）、强直-阵挛性发作频率（11.68±1.36）明显低于常规组，差异有统计学意义（P<0.05）。
左乙拉西坦治疗儿童癫痫效果确切，能有效改善患者认知功能，降低肌阵挛性发作和强直-阵挛性发作频率，具有较高的推广应用价值。
