Program in Cancer Biology, Vanderbilt University, Nashville, Tennessee.
Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Cancer Res. 2019 Aug 15;79(16):4003-4008. doi: 10.1158/0008-5472.CAN-19-0617. Epub 2019 Jul 30.
Metabolic reprogramming of cancer cells and the tumor microenvironment are emerging as key factors governing tumor growth, metastasis, and response to therapies including immune checkpoint inhibitors. It has been recognized that rapidly proliferating cancer cells, tumor-infiltrating lymphocytes, and vascular endothelial cells compete for oxygen and nutrients. Tumor cells and other cell types in the microenvironment not only compete for nutrients, but they also simultaneously produce immunosuppressive metabolites, leading to immune escape. In addition, commensal microbial metabolites can influence regulatory T cells and inflammation in the intestine, thus playing an essential role in cancer prevention or cancer promotion. In this review, we summarize recent advances on metabolic interactions among various cell types in the tumor microenvironment, with a focus on how these interactions affect tumor immunity. We also discuss the potential role of blood vessel metabolism in regulating immune cell trafficking and activation.
肿瘤细胞和肿瘤微环境的代谢重编程正在成为控制肿瘤生长、转移以及对包括免疫检查点抑制剂在内的治疗方法的反应的关键因素。人们已经认识到，快速增殖的癌细胞、肿瘤浸润淋巴细胞和血管内皮细胞争夺氧气和营养物质。肿瘤细胞和微环境中的其他细胞类型不仅争夺营养物质，而且还同时产生免疫抑制代谢物，导致免疫逃逸。此外，共生微生物代谢物可以影响肠道中的调节性 T 细胞和炎症，从而在癌症预防或促进中发挥重要作用。在这篇综述中，我们总结了肿瘤微环境中各种细胞类型之间代谢相互作用的最新进展，重点讨论了这些相互作用如何影响肿瘤免疫。我们还讨论了血管代谢在调节免疫细胞迁移和激活中的潜在作用。
