文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

当 alpha 遇见 beta，肥大细胞就过度活跃了。

When alpha meets beta, mast cells get hyper.

机构信息

Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology, and Research), Singapore.

Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology, and Research), Singapore

出版信息

J Exp Med. 2019 Oct 7;216(10):2229-2230. doi: 10.1084/jem.20191169. Epub 2019 Jul 30.

DOI:10.1084/jem.20191169
PMID:31362981
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6780996/
Abstract

The evolutionary conservation of the catalytically inactive α-tryptase gene has remained a mystery. In this issue of , Le et al. (2019. https://doi.org/10.1084/jem.20190701) unveil the existence of a novel but natural tryptase, heteromeric α/β-tryptase, a critical mediator of α-tryptase-associated diseases.

摘要

催化无活性α-胰蛋白酶基因的进化保守性一直是个谜。在本期的《 》杂志中，Le 等人（2019. https://doi.org/10.1084/jem.20190701）揭示了一种新型但天然的胰蛋白酶，即异源二聚体α/β-胰蛋白酶的存在，它是与α-胰蛋白酶相关疾病的关键介质。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7d6/6780996/eae22e7897b0/JEM_20191169_Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7d6/6780996/b1f74b31e670/JEM_20191169_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7d6/6780996/eae22e7897b0/JEM_20191169_Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7d6/6780996/b1f74b31e670/JEM_20191169_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7d6/6780996/eae22e7897b0/JEM_20191169_Fig2.jpg

相似文献

[1]
When alpha meets beta, mast cells get hyper.

J Exp Med. 2019-7-30

[2]
Expression of a mast cell tryptase in the human monocytic cell lines U-937 and Mono Mac 6.

Scand J Immunol. 1993-10

[3]
Characterization of human gamma-tryptases, novel members of the chromosome 16p mast cell tryptase and prostasin gene families.

J Immunol. 2000-6-15

[4]
Chimerism, point mutation, and truncation dramatically transformed mast cell delta-tryptases during primate evolution.

J Allergy Clin Immunol. 2008-5

[5]
Identification and characterization of multiple forms of tryptase from human mast cells.

Arch Dermatol Res. 1999

[6]
Evaluation of the substrate specificity of human mast cell tryptase beta I and demonstration of its importance in bacterial infections of the lung.

J Biol Chem. 2001-7-13

[7]
Clinical relevance of inherited genetic differences in human tryptases: Hereditary alpha-tryptasemia and beyond.

Ann Allergy Asthma Immunol. 2021-12

[8]
cDNA sequence of two sheep mast cell tryptases and the differential expression of tryptase and sheep mast cell proteinase-1 in lung, dermis and gastrointestinal tract.

Clin Exp Allergy. 2000-6

[9]
Alpha-Tryptase as a Risk-Modifying Factor for Mast Cell-Mediated Reactions.

Curr Allergy Asthma Rep. 2024-4

[10]
Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3.

J Biol Chem. 1999-2-5

引用本文的文献

[1]
Mechanisms of allergen-specific immunotherapy for allergic rhinitis and food allergies.

Biosci Rep. 2020-4-30

本文引用的文献

[1]
The transcriptional program, functional heterogeneity, and clinical targeting of mast cells.

J Exp Med. 2017-9-4

[2]
Effect of tryptase inhibition on joint inflammation: a pharmacological and lentivirus-mediated gene transfer study.

Arthritis Res Ther. 2017-6-6

[3]
Tryptase inhibitors: a patent review.

Expert Opin Ther Pat. 2017-8

[4]
The Role of Mast Cell Specific Chymases and Tryptases in Tumor Angiogenesis.

Biomed Res Int. 2015

[5]
Targeting mast cells tryptase in tumor microenvironment: a potential antiangiogenetic strategy.

Biomed Res Int. 2014

[6]
Expression of alpha-tryptase and beta-tryptase by human basophils.

J Allergy Clin Immunol. 2004-6

[7]
Mast cell tryptase: a review of its physiology and clinical significance.

Anaesthesia. 2004-7

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索