当 alpha 遇见 beta，肥大细胞就过度活跃了。
When alpha meets beta, mast cells get hyper.
机构信息
Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology, and Research), Singapore.
Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology, and Research), Singapore
出版信息
J Exp Med. 2019 Oct 7;216(10):2229-2230. doi: 10.1084/jem.20191169. Epub 2019 Jul 30.
Abstract
The evolutionary conservation of the catalytically inactive α-tryptase gene has remained a mystery. In this issue of , Le et al. (2019. https://doi.org/10.1084/jem.20190701) unveil the existence of a novel but natural tryptase, heteromeric α/β-tryptase, a critical mediator of α-tryptase-associated diseases.
摘要
催化无活性α-胰蛋白酶基因的进化保守性一直是个谜。在本期的《 》杂志中，Le 等人（2019. https://doi.org/10.1084/jem.20190701）揭示了一种新型但天然的胰蛋白酶，即异源二聚体α/β-胰蛋白酶的存在，它是与α-胰蛋白酶相关疾病的关键介质。
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