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经皮胆红素测定在早产儿中的准确性。

The accuracy of transcutaneous bilirubinometry in preterm infants.

机构信息

Department of Neonatology, Zeynep Kamil Maternity and Children's Research and Training Hospital, Istanbul, Turkey.

Department of Neonatology, School of Medicine, Koc University, Istanbul, Turkey.

出版信息

J Perinatol. 2020 Feb;40(2):212-218. doi: 10.1038/s41372-019-0445-3. Epub 2019 Jul 30.

Abstract

OBJECTIVE

To evaluate the correlation between total serum and transcutaneous bilirubin and to determine the reliability of transcutaneous bilirubinometry for screening and monitoring of neonatal jaundice among preterms.

STUDY DESIGN

Ninety nine infants with gestational ages ≤34 weeks were prospectively enrolled. Babies were classified into three groups as; 24-28, 29-31, and 32-34 weeks. Total serum bilirubin and simultaneous transcutaneous bilirubin were measured before the onset of phototheraphy, during and at 24 h after discontinuing phototherapy.

RESULTS

Total serum bilirubin significantly correlated with transcutaneous bilirubin in the whole cohort (r = 0.867, p < 0.001) and in each group before, during and after phototheraphy. Hypotension was the only variable which effects the difference between two methods at postnatal first day of life (p = 0.039).

CONCLUSION

Transcutaneous bilirubin levels were highly correlated with total serum bilirubin levels even in 24-28 GW babies. Transcutaneous bilirubin may be useful for screening and monitoring of jaundice in very preterm newborns.

摘要

目的

评估总血清胆红素和经皮胆红素之间的相关性,并确定经皮胆红素测定法在早产儿中筛查和监测新生儿黄疸的可靠性。

研究设计

前瞻性纳入 99 名胎龄≤34 周的婴儿。将婴儿分为三组:24-28 周、29-31 周和 32-34 周。在开始光疗前、光疗期间和停止光疗后 24 小时测量总血清胆红素和同时的经皮胆红素。

结果

总血清胆红素与整个队列中的经皮胆红素显著相关(r=0.867,p<0.001),以及在光疗前、光疗期间和光疗后每个组中均相关。低血压是影响两种方法在新生儿出生后第一天差异的唯一变量(p=0.039)。

结论

即使在 24-28 周 GW 的婴儿中,经皮胆红素水平与总血清胆红素水平高度相关。经皮胆红素可能对极低出生体重儿的黄疸筛查和监测有用。

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