Grannell Louise
Alfred Health, Melbourne.
Aust Prescr. 2019 Jun;42(3):86-89. doi: 10.18773/austprescr.2019.025. Epub 2019 Jun 3.
Adherence to drug regimens is critical to optimise therapeutic outcomes. To aid adherence patient preferences must be discussed when considering the timing of doses, especially for chronic therapy The appropriate timing of administration should maximise therapeutic effects and minimise adverse reactions. If possible, doses should fit with the patient’s daily routines Check if drug absorption is affected by meals. Food may increase or decrease absorption, and may also improve gastric tolerance Non-steroidal anti-inflammatory drugs are usually taken with food. For patients with acute pain, administration without food may be acceptable The best time to take antihypertensive drugs is uncertain. Chronotherapy studies may clarify any influence of evening or morning doses on clinical outcomes
坚持药物治疗方案对于优化治疗效果至关重要。为了帮助患者坚持治疗，在考虑给药时间时必须讨论患者的偏好，尤其是对于长期治疗。给药的合适时间应使治疗效果最大化并使不良反应最小化。如果可能，剂量应符合患者的日常生活习惯。检查药物吸收是否受食物影响。食物可能会增加或减少吸收，也可能改善胃耐受性。非甾体抗炎药通常与食物一起服用。对于急性疼痛患者，空腹给药可能是可以接受的。服用抗高血压药物的最佳时间尚不确定。时间治疗研究可能会阐明早晚剂量对临床结果的任何影响。
