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髋关节置换术后新发术后心房颤动与老年患者 1 年死亡率的关系。

Association between new-onset postoperative atrial fibrillation and 1-year mortality in elderly patients after hip arthroplasty.

机构信息

Surgery Intensive Care Unit, China-Japan Friendship Hospital, Beijing, China.

Department of Orthopedic Surgery, China-Japan Friendship Hospital, Beijing, China.

出版信息

Aging Clin Exp Res. 2020 May;32(5):921-924. doi: 10.1007/s40520-019-01271-x. Epub 2019 Jul 30.

Abstract

BACKGROUND

The purpose of this study is to determine whether new-onset postoperative atrial fibrillation (NOPAF) among patients after hip arthroplasty can predict 1-year mortality.

METHODS

All patients over 65 years who underwent hip arthroplasty from January 2013 to December 2017 in a Chinese tertiary hospital were retrospectively analyzed. Patients with paroxysmal and persistent atrial fibrillation were ruled out. 2438 patients were identified to be eligible. The primary endpoint was 1-year mortality after the arthroplasty.

RESULTS

Among the 2438 patients, 101 (4.1%) had NOPAF and 2337 (95.9%) had not. Only the current use of beta blocker could predict the occurrence of NOPAF after hip arthroplasty. 1-year mortality for patients with NOPAF was significantly higher than that for patients without NOPAF (70.3% vs 19.0%; p < 0.001). Anti-arrhythmic and anticoagulant treatments were related to 1-year mortality, respectively. With multivariate analysis, NOPA was the most significant variable related to 1-year mortality (hazard ratio 7.8, 95% CI 2.9-24.6).

CONCLUSIONS

Among elderly patients after hip arthroplasty, 1-year mortality is increased significantly for patients with NOPAF.

摘要

背景

本研究旨在确定髋关节置换术后新发的心房颤动(NOPAF)是否可以预测 1 年死亡率。

方法

回顾性分析 2013 年 1 月至 2017 年 12 月在中国一家三级医院接受髋关节置换术的所有 65 岁以上患者。排除阵发性和持续性心房颤动患者。共确定 2438 例患者符合条件。主要终点是手术后 1 年的死亡率。

结果

在 2438 例患者中,101 例(4.1%)发生了 NOPAF,2337 例(95.9%)未发生。只有当前使用β受体阻滞剂才能预测髋关节置换术后 NOPAF 的发生。NOPAF 患者的 1 年死亡率明显高于无 NOPAF 患者(70.3%比 19.0%;p<0.001)。抗心律失常和抗凝治疗与 1 年死亡率相关。多变量分析显示,NOPA 是与 1 年死亡率最显著相关的变量(危险比 7.8,95%CI 2.9-24.6)。

结论

在髋关节置换术后的老年患者中,NOPAF 患者的 1 年死亡率显著增加。

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