多黏菌素：作用模式。

Polymyxins: Mode of Action.

机构信息

State Key Laboratory of Microbial Technology, Shandong University, Qingdao Campus, Qingdao, Shandong, People's Republic of China.

Department of Pharmacology and Therapeutics, University of Melbourne, Melbourne, Australia.

出版信息

Adv Exp Med Biol. 2019;1145:37-54. doi: 10.1007/978-3-030-16373-0_4.

DOI:10.1007/978-3-030-16373-0_4

PMID:31364070

Abstract

The dry antibiotic development pipeline coupled with the emergence of multi-drug resistant Gram-negative 'superbugs' has driven the revival of the polymyxin lipopeptide antibiotics. Understanding the mode of action of antibiotics is an important precursor for optimizing their use and development. This chapter provides a concise treatise of the current knowledge-based on the primary mode of action of polymyxins as well as recent developments in understanding of bacterial cell responses and secondary modes of action.

摘要

干燥的抗生素研发管道加上多药耐药革兰氏阴性“超级细菌”的出现，推动了多黏菌素脂肽类抗生素的复兴。了解抗生素的作用模式是优化其使用和开发的重要前提。本章基于多黏菌素的主要作用模式以及对细菌细胞反应和次要作用模式的最新理解，提供了一个简明的论述。