结论。

Conclusion.

机构信息

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville Campus, Melbourne, VIC, Australia.

出版信息

Adv Exp Med Biol. 2019;1145:363-364. doi: 10.1007/978-3-030-16373-0_21.

DOI:10.1007/978-3-030-16373-0_21

PMID:31364087

Abstract

This chapter briefly reviews the progress that has been made in understanding the key chemical, microbiological and pharmacological properties of the polymyxins since they were resurrected for clinical use around the start of the current century. Discussed are some of the key outcomes of the first three international conferences on the poymyxins, including publication of a consensus statement on a framework for redevelopment of these last-line antibiotics and international consensus guidelines for their optimal use in patients.

摘要

本章简要回顾了本世纪初重新应用多黏菌素以来，人们在理解其关键化学、微生物学和药理学特性方面取得的进展。文中讨论了前三次多黏菌素国际会议的部分重要成果，包括发布了关于重新开发这些最后一线抗生素的框架的共识声明和关于优化这些抗生素在患者中应用的国际共识指南。