Kirshon B, Wasserstrum N, Willis R, Herman G E, McCabe E R
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas.
Obstet Gynecol. 1988 Sep;72(3 Pt 2):462-4.
Intravenous cyclophosphamide was administered for severe exacerbation of systemic lupus erythematosus to a patient not known to be in the first trimester of pregnancy. The patient received no other medication except prednisone. Her neonate was born with multiple anomalies, including absent thumbs, cleft palate, low-set ears, and multiple eye abnormalities. These anomalies probably reflect teratogenic effects of cyclophosphamide, and indicate that judgment is required before its use in the first trimester. Furthermore, this case illustrates the need for effective contraception and repetitive pregnancy testing when potentially teratogenic agents are administered to presumably nonpregnant women in the reproductive age group.
一名未知已怀孕头三个月的系统性红斑狼疮严重加重患者接受了静脉注射环磷酰胺治疗。该患者除泼尼松外未接受其他药物治疗。她的新生儿出生时伴有多种畸形，包括拇指缺如、腭裂、低位耳和多种眼部异常。这些畸形可能反映了环磷酰胺的致畸作用，并表明在怀孕头三个月使用该药前需要谨慎判断。此外，该病例说明了当对育龄期可能未怀孕的妇女使用潜在致畸药物时，需要采取有效的避孕措施并反复进行妊娠检测。
