Schafer A I
Arch Intern Med. 1981 Mar;141(4):514-5.
The clinical teratogenicity of the new antileukemic chemotherapeutic agents administered to mothers early in the first trimester of pregnancy is not well defined. Cytarabine and thioguanine were given in identical doses to the same mother during the first trimester of two separate pregnancies. Both pregnancies resulted in viable babies, one with and one without congenital malformations. This case illustrates the highly unpredictable clinical effects on the fetus of chemotherapy early in pregnancy.
在妊娠头三个月早期给予母亲新型抗白血病化疗药物的临床致畸性尚未明确界定。在两次不同妊娠的头三个月期间，给同一位母亲给予相同剂量的阿糖胞苷和硫鸟嘌呤。两次妊娠均产下存活婴儿，其中一个有先天性畸形，另一个没有。该病例说明了妊娠早期化疗对胎儿的临床影响具有高度不可预测性。
