Asghariazar Vahid, Sakhinia Ebrahim, Mansoori Behzad, Mohammadi Ali, Baradaran Behzad
Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
J Cell Biochem. 2019 Dec;120(12):19274-19289. doi: 10.1002/jcb.29295. Epub 2019 Jul 31.
Lung cancer (LC) is the second common cancer for both women and men all over the world. Unfortunately, the number of LC deaths is increasing rapidly each year so early diagnosis of LC can be lifesaving. MicroRNAs are involved in multiple processes, such as cell differentiation, transcription, inflammation, proliferation, cell signaling, and apoptosis. In LC, microRNAs function as tumor suppressors (TS) or oncogenes depending on the targets. Changes in microRNAs expression level are related to tumor initiation, progression, and metastasis. MicroRNAs can regulate gene expression and thus affect the activity status of different signaling pathways including AKT, JAK-STAT, MAPK, TGF-β, WNT, and ERK signaling pathways. Positive or negative effects on drug resistance of LC are directly affected by microRNAs and their target genes. MicroRNAs can be beneficial in combination therapy with other drugs and chemotherapeutic agents for LC.
肺癌（LC）是全球男性和女性中第二常见的癌症。不幸的是，每年肺癌死亡人数都在迅速增加，因此肺癌的早期诊断可以挽救生命。微小RNA参与多种过程，如细胞分化、转录、炎症、增殖、细胞信号传导和细胞凋亡。在肺癌中，微小RNA根据其靶标发挥肿瘤抑制因子（TS）或癌基因的作用。微小RNA表达水平的变化与肿瘤的发生、发展和转移有关。微小RNA可以调节基因表达，从而影响包括AKT、JAK-STAT、MAPK、TGF-β、WNT和ERK信号通路在内的不同信号通路的活性状态。微小RNA及其靶基因直接影响肺癌耐药性的正负效应。微小RNA与其他药物和化疗药物联合治疗肺癌可能有益。
