Medical Biotechnology Research Center, Arak University of Medical Sciences, Arak, Iran.
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Biomed Pharmacother. 2022 Apr;148:112735. doi: 10.1016/j.biopha.2022.112735. Epub 2022 Feb 19.
Autophagy is conserved cellular machinery that degrades un-usable proteins and cellular components and has a crucial role in the pathogenesis and drug resistance of various diseases such as lung cancer (LC). Multiple types of endogenous molecules (i.e. miRNAs) have been found to regulate multiple biological processes, such as autophagy. Dysfunction of these molecules is associated with the onset and progression of a variety of human malignancies. Several studies had shown that some miRNAs could mediate autophagy activity in LC cells, which would affect drug resistance as a major problem in LC therapy. Therefore, identifying the underlying molecular targets of miRNAs and their function in autophagy pathways could develop new treatment interventions for LC patients. In this review, we will summarize the interplay between miRNAs, autophagy, and drug resistance of LC patients, as well as the genes and molecular pathways that are involved.
自噬是一种保守的细胞机制，可降解无用的蛋白质和细胞成分，在肺癌 (LC) 等多种疾病的发病机制和耐药性中起着至关重要的作用。已经发现多种内源性分子（即 miRNAs）可以调节多种生物学过程，如自噬。这些分子的功能障碍与多种人类恶性肿瘤的发生和发展有关。一些研究表明，一些 miRNAs 可以调节 LC 细胞中的自噬活性，这会影响 LC 治疗中的主要问题——耐药性。因此，确定 miRNAs 的潜在分子靶点及其在自噬途径中的功能，可能为 LC 患者开发新的治疗干预措施。在这篇综述中，我们将总结 miRNAs、自噬与 LC 患者耐药性之间的相互作用，以及涉及的基因和分子途径。
