Texier-Maugein J, Escoubas J, Fouche J, Mormede M
Laboratoire de Bactériologie, Hôpital Xavier-Arnozan, Pessac.
Pathol Biol (Paris). 1988 May;36(5):540-3.
This study reports 45 cases of respiratory tract infection associated with Branhamella catarrhalis, diagnosed by bacteriological examination out of 980 sputum samples studied over a 6 months period. These infections were observed mainly in patients with chronic respiratory disease (68.9%). More than half of the isolates were found in pure culture, others were isolated from mixed infections most often with Haemophilus influenzae, Streptococcus pneumoniae or H. influenzae plus S. pneumoniae. 64.7% of Branhamella catarrhalis isolates produced beta-lactamase. In vitro antimicrobial susceptibility testing demonstrated that the B. catarrhalis isolates, including beta-lactamase producing strains, were very susceptible to clavulanic acid plus amoxycillin (MIC90:0.12 microgram/ml) as well as to doxycycline and erythromycin (MIC90:0.5 microgram/ml).
本研究报告了45例与卡他布兰汉菌相关的呼吸道感染病例,这些病例是在6个月内对980份痰液样本进行细菌学检查后诊断出来的。这些感染主要发生在慢性呼吸道疾病患者中(68.9%)。超过一半的分离株是在纯培养物中发现的,其他的则是从混合感染中分离出来的,最常见的是与流感嗜血杆菌、肺炎链球菌或流感嗜血杆菌加肺炎链球菌混合感染。64.7%的卡他布兰汉菌分离株产生β-内酰胺酶。体外抗菌药敏试验表明,卡他布兰汉菌分离株,包括产β-内酰胺酶的菌株,对克拉维酸加阿莫西林(MIC90:0.12微克/毫升)以及强力霉素和红霉素(MIC90:0.5微克/毫升)非常敏感。