Park Jun Seok, Park Jae Hong, Seo Kyoung Won, Song Kun Ho
College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea.
Department of Animal Resources Science, Dankook University, Cheonan 31116, Korea.
J Vet Sci. 2019 Jul;20(4):e43. doi: 10.4142/jvs.2019.20.e43.
Chronic mitral valve disease (CMVD) is the most common cardiovascular disease in dogs, causing decreased cardiac output that results in poor tissue perfusion and tissue damage to kidneys, pancreas, and other organs. The purpose of this study was to evaluate the relationships between heart disease severity and N-terminal pro B-type natriuretic peptide (NT-proBNP) and lipase in dogs with CMVD, as well as to evaluate longitudinal changes in these values. A total of 84 dogs participated in this 2015 to 2017 study. Serum values of NT-proBNP and lipase were analyzed; radiography was used to measure the vertebral heart score and assess various echocardiographic values. NT-proBNP showed a strong positive correlation with increasing stage of heart disease; lipase showed a mild positive correlation with heart disease stage. When the three values (NT-proBNP, lipase and month) were continuously measured at 6-month intervals, all showed a correlation with the increasing length of the disease.
慢性二尖瓣疾病（CMVD）是犬类最常见的心血管疾病，可导致心输出量减少，进而引起组织灌注不足以及肾脏、胰腺和其他器官的组织损伤。本研究的目的是评估患有CMVD的犬类心脏病严重程度与N末端B型利钠肽原（NT-proBNP）和脂肪酶之间的关系，并评估这些值的纵向变化。共有84只犬参与了这项2015年至2017年的研究。分析了NT-proBNP和脂肪酶的血清值；使用放射照相术测量椎体心脏评分并评估各种超声心动图值。NT-proBNP与心脏病进展阶段呈强正相关；脂肪酶与心脏病阶段呈轻度正相关。当每6个月连续测量这三个值（NT-proBNP、脂肪酶和月份）时，所有值均与疾病持续时间的增加相关。
