Wu Hui, Chang Weiyu, Deng Yanglin, Chen Xinli, Ding Yongli, Li Xuesong, Dong Liang
The First Affiliated Hospital of Kunming Medical University Department of Pharmacy Kunming Yunnan People's Republic of China Department of Pharmacy, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People's Republic of China.
Chinese Academy of Sciences Yunnan Observatories Kunming Yunnan People's Republic of China Yunnan Observatories, Chinese Academy of Sciences, Kunming, Yunnan, People's Republic of China.
Braz J Cardiovasc Surg. 2019 Dec 1;34(6):674-679. doi: 10.21470/1678-9741-2018-0306.
To study the response of myocardial ischemia/reperfusion injury (MI/RI) in rats to simulated geomagnetic activity.
In a simulated strong geomagnetic outbreak, the MI/RI rat models were radiated, and their area of myocardial infarction, hemodynamic parameters, creatine kinase (CK), lactate dehydrogenase (LDH), melatonin, and troponin I values were measured after a 24-hour intervention.
Our analysis indicates that the concentrations of troponin I in the geomagnetic shielding+operation group were lower than in the radiation+operation group (P<0.05), the concentrations of melatonin in the shielding+operation group and normal+operation group were higher than in the radiation + operation group (P<0.01), and the concentrations of CK in the shielding + operation group were lower than in the radiation + operation group and normal + operation group (P<0.05). Left ventricular developed pressure (LVDP) and ± dP/dtmax in the radiation+operation group were lower than in the shielding + operation group and normal+operation group (P<0.01). Left ventricular end-diastolic pressure (LEVDP) in the shielding + operation group was higher than in the normal + operation group (P<0.05). There was no significant difference in area of myocardial infarction and LDH between the shielding + operation group and the radiation + operation group.
Our data suggest that geomagnetic activity is important in regulating myocardial reperfusion injury. The geomagnetic shielding has a protective effect on myocardial injury, and the geomagnetic radiation is a risk factor for aggravating the cardiovascular and cerebrovascular diseases.
研究大鼠心肌缺血/再灌注损伤（MI/RI）对模拟地磁活动的反应。
在模拟强地磁爆发时，对MI/RI大鼠模型进行辐射，干预24小时后测量其心肌梗死面积、血流动力学参数、肌酸激酶（CK）、乳酸脱氢酶（LDH）、褪黑素和肌钙蛋白I值。
分析表明，地磁屏蔽+手术组肌钙蛋白I浓度低于辐射+手术组（P<0.05），屏蔽+手术组和正常+手术组褪黑素浓度高于辐射+手术组（P<0.01），屏蔽+手术组CK浓度低于辐射+手术组和正常+手术组（P<0.05）。辐射+手术组的左心室舒张末压（LVDP）和±dP/dtmax低于屏蔽+手术组和正常+手术组（P<0.01）。屏蔽+手术组的左心室舒张末压（LEVDP）高于正常+手术组（P<0.05）。屏蔽+手术组与辐射+手术组之间的心肌梗死面积和LDH无显著差异。
我们的数据表明，地磁活动在调节心肌再灌注损伤中起重要作用。地磁屏蔽对心肌损伤有保护作用，地磁辐射是加重心脑血管疾病的危险因素。
