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以双侧面神经麻痹和脑膜炎为表现的川崎病:一例报告及文献复习

Kawasaki disease manifesting as bilateral facial nerve palsy and meningitis: a case report and literature review.

作者信息

Zhang Bo, Hao Yunpeng, Zhang Yanfeng, Yang Nuo, Li Hang, Liang Jianmin

机构信息

1 Department of Pediatric Neurology, the First Hospital of Jilin University, Changchun, Jilin, China.

2 Department of Hepatobiliary Pancreatic Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.

出版信息

J Int Med Res. 2019 Aug;47(8):4014-4018. doi: 10.1177/0300060519854287. Epub 2019 Jul 31.

Abstract

BACKGROUND

Kawasaki disease (KD) is an acute multisystem vasculitic syndrome that predominantly affects infants and young children. Neurological complications are rare in patients with KD and the diagnosis is challenging. We report a case of KD that manifested as bilateral facial nerve palsy and meningitis.

CASE REPORT

A 6-month-old boy presented with a 10-day history of fever. Four days before admission, the patient developed a rash, conjunctival injection, perioral and perianal excoriation, and bilateral facial nerve palsy. Brain magnetic resonance imaging was normal. Echocardiography showed dilated coronary arteries and coronary artery aneurysms. A cerebrospinal fluid examination showed an elevated leukocyte count. A diagnosis of KD was made, and the patient was treated with gamma globulin and aspirin. The patient’s fever subsided on the following day and the right-sided facial nerve palsy was relieved 1 month later. An 18-month follow-up showed that the left-sided facial nerve palsy persisted and the patient’s condition remained stable.

CONCLUSION

KD manifesting as bilateral facial nerve palsy and meningitis is extremely rare. Clinicians should be aware of this condition, and early diagnosis and appropriate treatment should be emphasized.

摘要

背景

川崎病(KD)是一种主要影响婴幼儿的急性多系统血管炎综合征。KD患者出现神经并发症较为罕见,诊断具有挑战性。我们报告一例表现为双侧面神经麻痹和脑膜炎的KD病例。

病例报告

一名6个月大男孩有10天发热病史。入院前4天,患者出现皮疹、结膜充血、口周和肛周皮肤破损以及双侧面神经麻痹。脑部磁共振成像正常。超声心动图显示冠状动脉扩张和冠状动脉瘤。脑脊液检查显示白细胞计数升高。诊断为KD,患者接受了丙种球蛋白和阿司匹林治疗。患者次日体温下降,1个月后右侧面神经麻痹缓解。18个月的随访显示左侧面神经麻痹持续存在,患者病情保持稳定。

结论

表现为双侧面神经麻痹和脑膜炎的KD极为罕见。临床医生应意识到这种情况,并强调早期诊断和适当治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2eb/6726819/64c05c06b433/10.1177_0300060519854287-fig1.jpg

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