健康相关生命质量与老年人群认知衰退：NeuroDemeNPsia 研究初步结果。
Health Related Quality of Life and Cognitive Decline in Older Populations: Preliminary Results From NeuroDemeNPsia Study.
机构信息
University of the Basque Country, Donostia-San Sebastian, Spain.
Maynooth University, Ireland.
出版信息
J Appl Gerontol. 2020 Jun;39(6):618-626. doi: 10.1177/0733464819866587. Epub 2019 Jul 31.
To measure Health Related Quality of Life (HRQoL) in people with different primary degenerative dementias and compare them with 50+ years old older individuals with mild cognitive impairment (MCI) and healthy controls (HCs). In all, 45 participants suffered from Alzheimer's disease (AD) dementia, 27 from Lewy body dementia (LBD), 17 from frontotemporal dementia (FTD), 43 from MCI, and 31 HCs ( = 163). The 12-Item Short Form Health Survey, version 2 (SF-12-v2) and Mini Mental State Examination were administered. Reisberg's Global Deterioration Scale (GDS) was completed by a neurologist. HRQoL indices obtained via the SF-12-v2 were compared between different subgroups. Physical Function, Physical Role, Emotional Role, and Physical Summary Composite scores showed the best scores for patients with AD, followed by HC and MCI, and finally FTD and LBD. A differentiated profile in HRQoL is shown in dementia subgroups, and may be useful to support differential diagnosis.
目的
测量不同原发性退行性痴呆患者的健康相关生活质量（HRQoL），并将其与轻度认知障碍（MCI）和健康对照组（HCs）的 50 岁以上老年人进行比较。共有 45 名参与者患有阿尔茨海默病（AD）痴呆，27 名患有路易体痴呆（LBD），17 名患有额颞叶痴呆（FTD），43 名患有 MCI，31 名 HCs（= 163）。使用 12 项简短健康调查量表，第二版（SF-12-v2）和简易精神状态检查（MMSE）进行评估。神经病学家完成了里夫斯全球衰退量表（GDS）。通过 SF-12-v2 获得的 HRQoL 指数在不同亚组之间进行了比较。身体功能、身体角色、情感角色和身体总括综合评分显示 AD 患者的得分最高，其次是 HC 和 MCI，最后是 FTD 和 LBD。在痴呆亚组中显示出不同的 HRQoL 特征，这可能有助于支持鉴别诊断。
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