一种肿瘤微环境模型与质谱系统相结合，用于探测载药纳米颗粒的代谢。

A tumor microenvironment model coupled with a mass spectrometry system to probe the metabolism of drug-loaded nanoparticles.

机构信息

CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, People's Republic of China.

出版信息

Chem Commun (Camb). 2019 Aug 22;55(69):10218-10221. doi: 10.1039/c9cc04628c.

DOI:10.1039/c9cc04628c

PMID:31364634

Abstract

This study describes a novel integrated microfluidic platform with microvessel network channels which are connected to an electrospray ionization-mass spectrometer (ESI-MS), allowing real-time probing of nanoparticle (NP) drug delivery in vascular niche around tumors and understanding the drug delivery efficacy in a realistic tumor microenvironment.

摘要

本研究描述了一种新颖的集成微流控平台，该平台具有与电喷雾电离-质谱仪（ESI-MS）相连的微血管网络通道，可实时探测肿瘤周围血管龛内的纳米颗粒（NP）药物输送，并了解在真实肿瘤微环境中的药物输送效果。