Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, 130024, P. R. China.
The First Hospital of Jilin University, Xinmin Street, Changchun, Jilin 130021, P. R. China.
J Mater Chem B. 2019 Jul 31;7(30):4717-4724. doi: 10.1039/c9tb01165j.
Near-infrared (NIR) responsive agents for cancer bioimaging and photothermal therapy are available and significant. Herein, we employed two easily available dyes, boron-dipyrromethane and coumarin, to synthesize a pair of coumarin-borondipyrromethane dyes with different conjugate degrees (BDC and BSC). The difference in conjugate degree made their photophysical properties poles apart. After the self-assembling of BDC and BSC, the newly constructed nanoparticles (BDC NPs and BSC NPs) demonstrated good biocompatibility. Moreover, BDC NPs exhibited a good photothermal effect under irradiation of 808 nm laser, which could effectively inhibit the growth of HeLa cells, and BSC NPs could quickly show a conspicuous fluorescence in the HeLa cells. The exploration demonstrates that the two organic dyes prepared with different conjugation degrees could provide new options for photothermal therapy of cancer and rapid bioimaging.
近红外（NIR）响应试剂在癌症生物成像和光热治疗方面具有重要作用。本文采用两种易得的染料，硼二吡咯甲烷和香豆素，合成了一对具有不同共轭度的香豆素-硼二吡咯甲烷染料（BDC 和 BSC）。共轭度的差异使它们的光物理性质截然不同。BDC 和 BSC 自组装后，新构建的纳米粒子（BDC NPs 和 BSC NPs）表现出良好的生物相容性。此外，BDC NPs 在 808nm 激光照射下表现出良好的光热效应，能有效抑制 HeLa 细胞的生长，而 BSC NPs 能在 HeLa 细胞中迅速显示出明显的荧光。该研究表明，用不同共轭度制备的两种有机染料可为癌症的光热治疗和快速生物成像提供新的选择。
