School of Biomedical Engineering, Sun Yat-sen University, Guangzhou, 510275, Guangdong, P. R. China.
Research Institute of Sun Yat-Sen University in Shenzhen, Shenzhen, 518057, Guangdong, P. R. China.
Adv Healthc Mater. 2019 Sep;8(17):e1900670. doi: 10.1002/adhm.201900670. Epub 2019 Jul 31.
Hydrogels based on natural polymers have bright application prospects in biomedical fields due to their outstanding biocompatibility and biodegradability. However, the poor mechanical performances of pure natural polymer-based hydrogels greatly limit their application prospects. Recently, a variety of strategies has been applied to prepare natural polymer-based hydrogels with enhanced mechanical properties, which generally exhibit stiffening, strengthening, and stretchable behaviors. This article summarizes the recent progress of natural polymer-based hydrogels with enhanced mechanical properties. From a structure point of view, four kinds of hydrogel are reviewed; double network hydrogels, nanocomposite hydrogels, click chemistry-based hydrogels, and supramolecular hydrogels. For each typical hydrogel, its preparation, structure, and mechanical performance are introduced in detail. At the end of this article, the current challenges and future prospects of hydrogels based on natural polymers are discussed and it is pointed out that 3D printing may offer a new platform for the development of natural polymer-based hydrogels.
基于天然聚合物的水凝胶由于其出色的生物相容性和可生物降解性，在生物医学领域具有广阔的应用前景。然而，纯天然聚合物基水凝胶的机械性能较差，极大地限制了其应用前景。最近，已经应用了多种策略来制备具有增强机械性能的天然聚合物基水凝胶，这些水凝胶通常表现出变硬、增强和可拉伸的行为。本文总结了具有增强机械性能的天然聚合物基水凝胶的最新进展。从结构的角度来看，综述了四种水凝胶：双网络水凝胶、纳米复合水凝胶、点击化学水凝胶和超分子水凝胶。对于每种典型的水凝胶，详细介绍了其制备、结构和机械性能。在本文的最后，讨论了基于天然聚合物的水凝胶的当前挑战和未来前景，并指出 3D 打印可能为天然聚合物基水凝胶的发展提供新的平台。
