Jeon Juya, Subramani Shri Venkatesh, Lee Kok Zhi, Elizondo-Benedetto Santiago, Zayed Mohamed Adel, Zhang Fuzhong
Department of Energy, Environmental & Chemical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.
Section of Vascular Surgery, Department of Surgery, Washington University School of Medicine in St. Louis, Saint Louis, MO 63130, USA.
Polymers (Basel). 2025 Apr 1;17(7):959. doi: 10.3390/polym17070959.
Adhesive hydrogels with tunable mechanical properties and strong adhesion to wet, dynamic tissues have emerged as promising materials for tissue repair, with potential applications in wound closure, hemorrhage control, and surgical adhesives. This review highlights the key design principles, material classifications, and recent advances in adhesive hydrogels designed for vascular repair. The limitations of existing adhesive hydrogels, including insufficient mechanical durability, suboptimal biocompatibility, and challenges in targeted delivery, are critically evaluated. Furthermore, innovative strategies-such as incorporating self-healing capabilities, developing stimuli-responsive systems, integrating functional nanocomposites, and employing advanced fabrication techniques like 3D bioprinting-are discussed to enhance adhesion, mechanical stability, and vascular tissue regeneration. While significant progress has been made, further research and optimization are necessary to advance these materials toward clinical translation, offering a versatile and minimally invasive alternative to traditional vascular repair techniques.
具有可调机械性能且对湿润、动态组织具有强粘附力的粘性水凝胶已成为组织修复领域颇具前景的材料，在伤口闭合、止血和手术粘合剂方面具有潜在应用。本综述重点介绍了用于血管修复的粘性水凝胶的关键设计原则、材料分类和最新进展。对现有粘性水凝胶的局限性进行了批判性评估，包括机械耐久性不足、生物相容性欠佳以及靶向递送方面的挑战。此外，还讨论了一些创新策略，如融入自愈能力、开发刺激响应系统、整合功能纳米复合材料以及采用3D生物打印等先进制造技术，以增强粘附力、机械稳定性和血管组织再生能力。尽管已取得重大进展，但仍需进一步研究和优化，以使这些材料向临床转化迈进，为传统血管修复技术提供一种通用且微创的替代方案。
