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BSA 稳定的四苯乙烯纳米晶体作为聚集诱导增强电化学发光发射体用于超灵敏 microRNA 分析。

BSA stabilized tetraphenylethylene nanocrystals as aggregation-induced enhanced electrochemiluminescence emitters for ultrasensitive microRNA assay.

机构信息

Key Laboratory of Luminescent and Real-Time Analytical Chemistry, Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.

出版信息

Chem Commun (Camb). 2019 Aug 15;55(67):9959-9962. doi: 10.1039/c9cc04660g.

DOI:10.1039/c9cc04660g
PMID:31364996
Abstract

On the basis of BSA stabilized tetraphenylethylene nanocrystals (BSA-TPE NCs) as aggregation-induced enhanced electrochemiluminescence (ECL) emitters with high ECL efficiency and good biocompatibility, as well as molecular recognition between β-CD and ferrocene, an ultrasensitive and versatile ECL biosensing platform was constructed to achieve microRNA detection in cancer cells.

摘要

基于 BSA 稳定的四苯乙烯纳米晶体(BSA-TPE NCs)作为具有高 ECL 效率和良好生物相容性的聚集诱导增强电化学发光(ECL)发射器,以及β-CD 与二茂铁之间的分子识别,构建了一种超灵敏且多功能的 ECL 生物传感平台,用于实现癌细胞中 microRNA 的检测。

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