通过铱催化的 C-H 活化实现 1,2,4-噻二唑与马来酰亚胺的区域选择性 C-C 交叉偶联。
Regioselective C-C cross-coupling of 1,2,4-thiadiazoles with maleimides through iridium-catalyzed C-H activation.
机构信息
The Key Laboratory for Medical Tissue Engineering, College of Medical Engineering, Jining Medical University, P. R. China.
出版信息
Org Biomol Chem. 2019 Sep 7;17(33):7664-7668. doi: 10.1039/c9ob01539f. Epub 2019 Jul 31.
PMID:31365018
Abstract
A regioselective C-C cross-coupling of 1,2,4-thiadiazoles with maleimides through iridium catalysis was developed. This transformation tactically linked the 1,2,4-thiadiazoles and succinimides together, and the novel molecules formed may have potential biological activity.
摘要
通过铱催化，发展了 1,2,4-噻二唑与马来酰亚胺的区域选择性 C-C 交叉偶联。这种转化策略性地将 1,2,4-噻二唑和琥珀酰亚胺连接在一起，形成的新分子可能具有潜在的生物活性。
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