铱催化1,2,4-噻二唑与磺酰叠氮化物在水中的区域选择性C-H磺酰胺化反应
Iridium-catalyzed regioselective C-H sulfonamidation of 1,2,4-thiadiazoles with sulfonyl azides in water.
作者信息
Cao Xian-Ting, Wei Su-Ning, Sun Hao-Tian, Li Meng, Zheng Zuo-Ling, Wang Guannan
机构信息
College of Medical Engineering, Key Laboratory for Medical Functional Nanomaterials, Jining Medical University Jining 272067 China
出版信息
RSC Adv. 2021 Jun 22;11(36):22000-22004. doi: 10.1039/d1ra04450h. eCollection 2021 Jun 21.
Abstract
We have developed a regioselective C-N cross-coupling of 1,2,4-thiadiazoles with sulfonyl azides through iridium catalysis in water. This method tactically linked the 1,2,4-thiadiazoles and sulfonamides together, and the novel molecules increased the diversity of 1,2,4-thiadiazoles which may have potential applications.
摘要
我们通过铱催化在水中实现了1,2,4-噻二唑与磺酰叠氮的区域选择性C-N交叉偶联。该方法巧妙地将1,2,4-噻二唑与磺酰胺连接在一起，这些新型分子增加了1,2,4-噻二唑的多样性，可能具有潜在应用价值。
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