Şimşek Ayşe, Turan Özlem, Çiftel Murat, Kardelen Fırat, Durmaz Erdem, Özdem Sebahat, Akçurin Gayaz, Ertuğ Halil
Departments of Pediatric Cardiology, Akdeniz University Faculty of Medicine, Antalya, Turkey.
Departments of Endocrinology Akdeniz University Faculty of Medicine, Antalya, Turkey.
Turk J Pediatr. 2018;60(6):633-641. doi: 10.24953/turkjped.2018.06.003.
Şimşek A, Turan Ö, Çiftel M, Kardelen F, Durmaz E, Özdem S, Akçurin G, Ertuğ H. Evaluation of left ventricular functions with twodimensional speckle-tracking echocardiography (2D-STE) and N-terminal ProBNP in diabetic children. Turk J Pediatr 2018; 60: 633-641. The purpose of this study was to examine the existence of subclinical left ventricular dysfunction by using 2D-STE and NT-ProBNP levels in children and adolescent patients with type 1 diabetes mellitus. Furthermore, it was also aimed to investigate the effects of the diabetes duration and the metabolic control of the disease on cardiac functions. The patient group was composed of 63 children who were being followed up for the type 1 diabetes mellitus. The control group was composed of 36 healthy children who were of the similar age. Patients with type 1 diabetes mellitus were divided into groups; according to the duration of the disease; group 1: 3-5 years, group 2: 6-10 years of follow-up. The conventional echocardiography and 2D-STE were applied to all of the patients and control individuals. NT-Pro BNP level was measured in the diabetes group. In the conventional echocardiographic examination; there was no difference between the patient and control groups in terms of left ventricular systolic functions, left ventricular diastolic functions; late-diastolic flow velocity in mitral valve (A) values increased and E-wave/A-wave ratio (E/A ) values decreased in diabetes mellitus patients. According to the 2D-STE results; global longitudinal strain, (-17.28±2.24 vs. -19.49±2.22; p < 0.05) and circumferential strain (-12.86±3.19 vs. -17.71±4.62; p < 0.05) were lower in diabetic patients compared to the parameters of control group individuals. There was no difference between levels of NT-ProBNP of the group 1 and group 2 diabetes mellitus patients. Our study showed that there was a dysfunction on the left ventricular systolic functions of the patients with type 1 diabetes mellitus. NT-Pro BNP levels were not considered as a distinguishing factor for the early stages of diabetes mellitus.
希姆谢克A、图兰Ö、奇夫泰尔M、卡德伦F、杜尔马兹E、厄兹德姆S、阿克楚林G、埃尔图赫H。二维斑点追踪超声心动图（2D-STE）和N端脑钠肽前体（NT-ProBNP）评估糖尿病儿童左心室功能。《土耳其儿科学杂志》2018年；60：633 - 641。本研究的目的是通过二维斑点追踪超声心动图（2D-STE）和NT-ProBNP水平，检查1型糖尿病儿童和青少年患者亚临床左心室功能障碍的存在情况。此外，还旨在研究糖尿病病程和疾病代谢控制对心脏功能的影响。患者组由63名接受1型糖尿病随访的儿童组成。对照组由36名年龄相仿的健康儿童组成。1型糖尿病患者根据病程分组；第1组：病程3 - 5年，第2组：随访6 - 10年。对所有患者和对照个体进行了传统超声心动图和二维斑点追踪超声心动图（2D-STE）检查。在糖尿病组中测量了NT-Pro BNP水平。在传统超声心动图检查中；患者组和对照组在左心室收缩功能、左心室舒张功能方面没有差异；糖尿病患者二尖瓣舒张晚期血流速度（A）值升高，E波/A波比值（E/A）降低。根据二维斑点追踪超声心动图（2D-STE）结果；与对照组个体参数相比，糖尿病患者的整体纵向应变（-17.28±2.24对-19.49±2.22；p < 0.05）和圆周应变（-12.86±3.19对-17.71±4.62；p < 0.05）较低。1型糖尿病第1组和第2组患者的NT-ProBNP水平没有差异。我们的研究表明，1型糖尿病患者存在左心室收缩功能障碍。NT-Pro BNP水平不被认为是糖尿病早期的鉴别因素。
