Saavedra Maira Arias, Aimo Carolina, Andrade Jose Astudillo, Alvarez Damaris, Sequeira Gabriel, Kerzberg Eduardo
Department of Rheumatology, Hospital J. M. Ramos Mejía, Buenos Aires, Argentina.
Eur J Rheumatol. 2019 Apr 1;6(2):94-97. doi: 10.5152/eurjrheum.2019.18182. Print 2019 Apr.
To assess key aspects of transportation and storage of biological therapies (BTs) on the part of the patients, from the time they collect them from the pharmacy up until the moment of administration.
This was a cross-sectional study in the form of a survey completed by outpatients older than 18 years who were administered BTs. The survey was carried out by the authors between August 2016 and January 2017.
A total of 83 outpatients were interviewed (mean age, 53; standard deviation, 15; 76% female). Sixty percent had rheumatoid arthritis, 24% had psoriatic arthritis, and 16% sustained other rheumatic and inflammatory diseases. Twenty percent had not been informed of the importance of proper refrigeration when they were first prescribed BTs; 77% had acquired the medication at least 7 days before administration; 28% had misplaced the drug in the fridge (65% of them in the freezer); 90% was unaware of the temperature range at which the BT should be kept in the fridge, and only one (1%) of them had once used a thermometer to find out the fridge temperature. Fifty-three percent had suffered frequent power outages the previous summer, 22% had experienced blackouts longer than 48 hours; 37% had taken the BT to another house to avoid wasting it, and four (5%) patients had disposed of the drug due to a prolonged power outage.
Upon prescribing BTs, it is imperative that physicians brief patients on the relevance of suitable transportation and storage methods, and a treatment failure should prompt a thorough assessment of transportation and storage conditions.
评估患者在从药房领取生物疗法药物(BTs)直至给药期间,BTs运输与储存的关键环节。
本研究为横断面调查,由接受BTs治疗的18岁以上门诊患者完成问卷调查。调查由作者于2016年8月至2017年1月期间开展。
共访谈了83名门诊患者(平均年龄53岁;标准差15;76%为女性)。60%患有类风湿关节炎,24%患有银屑病关节炎,16%患有其他风湿性和炎性疾病。20%在首次开具BTs处方时未被告知正确冷藏的重要性;77%在给药前至少7天领取了药物;28%将药物误放在冰箱中(其中65%放在冷冻室);90%不知道BTs在冰箱中应保持的温度范围,只有1人(1%)曾使用温度计测量冰箱温度。53%在前一年夏天经常停电,22%经历了超过48小时的停电;37%曾将BTs带到另一处住所以免浪费,4名(5%)患者因长时间停电而丢弃了药物。
开具BTs处方时,医生必须向患者说明合适的运输和储存方法的重要性,治疗失败时应全面评估运输和储存条件。