Bhoil Amit, Caw Hendrick, Vinjamuri Sobhan
Department of Nuclear Medicine, Royal Liverpool University Hospital, Liverpool, UK.
Nucl Med Commun. 2019 Sep;40(9):875-887. doi: 10.1097/MNM.0000000000001063.
Infection and inflammation are a common occurrence with orthopaedic procedures. Anatomical modalities can show the transformation in the disease process; however, these may occur later when compared with functional imaging modalities that are more likely to identify early disease patterns. Various molecular imaging modalities such as three-phase bone scintigraphy, labelled leucocyte scintigraphy, as well as radiolabelled antibiotics and immunoglobulins have been considered and have played key roles in assisting clinical decision-making. While 18F-flurodeoxyglucose (FDG) PET/computed tomography (CT) has been relatively well established in cancer pathways, it has the potential to contribute to surgical decision making for possible osteomyelitis post-metal implant surgery. In this article, we present a review of recently used tracers, and share our experience with using 18F-FDG PET/CT studies in a few diverse clinical settings related to post-metal implant osteomyelitis.
感染和炎症在骨科手术中很常见。解剖学检查方法可以显示疾病过程中的变化；然而，与更有可能识别早期疾病模式的功能成像方法相比，这些变化可能出现得较晚。各种分子成像方法，如三相骨闪烁显像、标记白细胞闪烁显像以及放射性标记抗生素和免疫球蛋白，都已得到考虑，并在协助临床决策中发挥了关键作用。虽然18F-氟脱氧葡萄糖（FDG）正电子发射断层显像/计算机断层扫描（PET/CT）在癌症诊断中已经相对成熟，但它有可能为金属植入物手术后可能发生的骨髓炎的手术决策提供帮助。在本文中，我们综述了最近使用的示踪剂，并分享了我们在一些与金属植入物后骨髓炎相关的不同临床环境中使用18F-FDG PET/CT研究的经验。
