Kim Seong-Jang, Ryul Shim Sung
Department of Nuclear Medicine, College of Medicine, Pusan National University.
BioMedical Research Institute for Convergence of Biomedical Science and Technology.
Nucl Med Commun. 2019 Sep;40(9):965-972. doi: 10.1097/MNM.0000000000001060.
The purpose of the current study was to investigate the diagnostic performance of radiolabeled amino acid PET for detection of pseudoprogression (PsP) of brain tumor after treatment through a systematic review and meta-analysis.
The PubMed and EMBASE database, from the earliest available date of indexing through 15 February 2019, were searched for studies evaluating the diagnostic performance of radiolabeled amino acid PET for detection of PsP. We determined the sensitivities and specificities across studies, calculated positive and negative likelihood ratios, and constructed summary receiver operating characteristic (SROC) curves.
Across seven results from six studies (971 patients), the pooled sensitivity was 0.89 [95% confidence interval (CI): 0.82-0.94] without heterogeneity (I2 = 0.0) and a pooled specificity of 0.88 (95% CI: 0.76-0.94) without heterogeneity (I2=29.4). Likelihood ratio syntheses gave an overall positive likelihood ratio of 7.3 (95% CI: 3.6-14.7) and negative likelihood ratio of 0.12 (95% CI: 0.07-0.21). The pooled diagnostic odds ratio (DOR) was 60 (95% CI: 23-152). Hierarchical SROC curve indicates that the areas under the curve (AUC) was 0.92 (95% CI: 0.90-0.94).
The current meta-analysis showed the good sensitivity and specificity of radiolabeled amino acid PET for detection of PsP of brain tumor after treatment. Also, the DOR was high and SROC curve showed high AUC value.
本研究旨在通过系统评价和荟萃分析，探讨放射性标记氨基酸PET对脑肿瘤治疗后假性进展（PsP）的诊断效能。
检索PubMed和EMBASE数据库，检索时间从最早收录日期至2019年2月15日，以查找评估放射性标记氨基酸PET对PsP诊断效能的研究。我们确定了各项研究的敏感性和特异性，计算了阳性和阴性似然比，并构建了汇总的受试者工作特征（SROC）曲线。
六项研究的七项结果（971例患者）显示，合并敏感性为0.89[95%置信区间（CI）：0.82-0.94]，无异质性（I2=0.0），合并特异性为0.88（95%CI：0.76-0.94），无异质性（I2=29.4）。似然比综合分析得出总体阳性似然比为7.3（95%CI：3.6-14.7），阴性似然比为0.12（95%CI：0.07-0.21）。合并诊断比值比（DOR）为60（95%CI：23-152）。分层SROC曲线表明曲线下面积（AUC）为0.92（95%CI：0.90-0.94）。
当前的荟萃分析表明，放射性标记氨基酸PET对脑肿瘤治疗后PsP具有良好的敏感性和特异性。此外，DOR较高，SROC曲线显示AUC值较高。
