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儿童及青少年和年轻成人脑肿瘤的PET-MRI融合成像：临床应用与挑战

Hybrid PET-MRI Imaging in Paediatric and TYA Brain Tumours: Clinical Applications and Challenges.

作者信息

Shankar Ananth, Bomanji Jamshed, Hyare Harpreet

机构信息

Children and Young People's Cancer Services, University College London hospitals NHS Foundation Trust, London NW1 2PG, UK.

Department of Nuclear Medicine, University College London hospitals NHS Foundation Trust, London NW1 2PG, UK.

出版信息

J Pers Med. 2020 Nov 9;10(4):218. doi: 10.3390/jpm10040218.

DOI:10.3390/jpm10040218
PMID:33182433
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7711629/
Abstract

(1) Background: Standard magnetic resonance imaging (MRI) remains the gold standard for brain tumour imaging in paediatric and teenage and young adult (TYA) patients. Combining positron emission tomography (PET) with MRI offers an opportunity to improve diagnostic accuracy. (2) Method: Our single-centre experience of F-fluorocholine (FCho) and fluoro-L-phenylalanine (FDOPA) PET-MRI in paediatric/TYA neuro-oncology patients is presented. (3) Results: Hybrid PET-MRI shows promise in the evaluation of gliomas and germ cell tumours in (i) assessing early treatment response and (ii) discriminating tumour from treatment-related changes. (4) Conclusions: Combined PET-MRI shows promise for improved diagnostic and therapeutic assessment in paediatric and TYA brain tumours.

摘要

(1) 背景：标准磁共振成像（MRI）仍是儿科、青少年及青年成人（TYA）患者脑肿瘤成像的金标准。将正电子发射断层扫描（PET）与MRI相结合提供了提高诊断准确性的机会。(2) 方法：介绍了我们在儿科/TYA神经肿瘤患者中使用F-氟胆碱（FCho）和氟-L-苯丙氨酸（FDOPA）PET-MRI的单中心经验。(3) 结果：混合PET-MRI在评估胶质瘤和生殖细胞肿瘤方面显示出前景，包括（i）评估早期治疗反应和（ii）区分肿瘤与治疗相关变化。(4) 结论：联合PET-MRI在儿科和TYA脑肿瘤的诊断和治疗评估方面显示出前景。

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