半乳糖凝集素-3：皮肤病学中一种非凡的多功能蛋白质。当前的认识与展望。
Galectin 3: an extraordinary multifunctional protein in dermatology. Current knowledge and perspectives.
作者信息
Pasmatzi Efstathia, Papadionysiou Christina, Monastirli Alexandra, Badavanis George, Tsambaos Dionysios
机构信息
Department of Dermatology, School of Medicine, Patras University, Rio-Patras, Greece.
Discipline of Dermatology, Center for Dermatologic Diseases, Limassol, Cyprus.
出版信息
An Bras Dermatol. 2019 Jul 29;94(3):348-354. doi: 10.1590/abd1806-4841.20198426.
Galectin 3 is a unique ~31 kDa protein that recognizes the N-acetyl-lactosamine structure of several glycoconjugates. It mainly occurs in epithelial and myeloid cells, but is also found in a variety of human cell types. In view of the crucial role played by galectin 3 in the regulation of cellular processes of essential importance and in the pathogenetic mechanisms of diverse disorders, it is not surprising that, particularly in the last three decades, the attention of the scientific community has been increasingly drawn to this extraordinary and multifunctional galectin. In this paper the authors summarize current knowledge on the expression of galectin 3 in normal and diseased human skin, its implications in the pathogenesis, diagnosis and prognosis of cutaneous disorders, and the perspectives of a novel approach to the treatment of the latter using galectin 3 or its inhibitors/antagonists.
半乳糖凝集素-3是一种独特的约31 kDa蛋白，可识别多种糖缀合物的N-乙酰乳糖胺结构。它主要存在于上皮细胞和髓样细胞中，但也存在于多种人类细胞类型中。鉴于半乳糖凝集素-3在至关重要的细胞过程调节以及多种疾病的发病机制中发挥的关键作用，尤其是在过去三十年中，科学界的注意力越来越多地被吸引到这种非凡的多功能半乳糖凝集素上，这并不奇怪。在本文中，作者总结了关于半乳糖凝集素-3在正常和患病人类皮肤中的表达、其在皮肤疾病发病机制、诊断和预后中的意义，以及使用半乳糖凝集素-3或其抑制剂/拮抗剂治疗后者的新方法的前景的当前知识。
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